Rabbit polyclonal antibody to KOX17 (K22)

Zinc~finger proteins contain DNA~binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc~finger proteins contain a Krueppel~type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF191 (Zinc finger protein 191), also known as ZNF24, KOX17, ZSCAN3 or RSG~A, is a 368 amino acid nuclear protein that belongs to the Krueppel C2H2~type zinc~finger protein family. Expressed in tissues throughout the body with the exception of heart, ZNF191 functions as a transcriptional repressor for a variety of proteins, such as VEGF (vascular endothelial growth factor), and is thought to be important for early embryonic development and cell proliferation. ZNF191 contains four C2H2~type zinc fingers and one SCAN box domain and, upon DNA damage, may be phosphorylated by ATM or ATR.