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Rabbit polyclonal antibody to TCF~4/12 (S616)

Western blot (WB) analysis of TCF~4/12 (S616) pAb at 1:500 dilution Lane1:SGC7901 whole cell lysate(20ug) Lane2:HepG2 whole cell lysate(40ug) Lane3:Jurkat whole cell lysate(40ug) Lane4:A549 whole cell lysate(40ug) Lane5:PMVEC whole cell lysate(40ug) Lane6:AML~12 whole cell lysate(40ug)

Rabbit polyclonal antibody to TCF~4/12 (S616)

货号：
53490
别名：
Transcription factor 4; TCF~4; Class B basic helix~loop~helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF~2; SL3~3 enhancer factor 2; SEF~2; TCF4; BHLHB19; ITF2; SEF2; Transcription factor 12; TCF~12; Class B basic helix~loop~helix protein 20; bHLHb20; DNA~binding protein HTF4; E~box~binding protein; Transcription factor HTF~4; TCF12; BHLHB20; HEB; HTF4
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P15884/Q99081
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to TCF~4/12 (S616)

Description
T cell factors (TCFs) comprise a family of DNA~binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt~1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF~4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β~catenin in a cooperative manner. This TCF~4/β~catenin complex induces expression of Wnt target genes, including multiple cancer~associated genes.

Description

T cell factors (TCFs) comprise a family of DNA~binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt~1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF~4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β~catenin in a cooperative manner. This TCF~4/β~catenin complex induces expression of Wnt target genes, including multiple cancer~associated genes.

Specification
Aliases	Transcription factor 4; TCF~4; Class B basic helix~loop~helix protein 19; bHLHb19; Immunoglobulin transcription factor 2; ITF~2; SL3~3 enhancer factor 2; SEF~2; TCF4; BHLHB19; ITF2; SEF2; Transcription factor 12; TCF~12; Class B basic helix~loop~helix protein 20; bHLHb20; DNA~binding protein HTF4; E~box~binding protein; Transcription factor HTF~4; TCF12; BHLHB20; HEB; HTF4
Swissprot	P15884/Q99081
clone	10H6H10
WB Predicted band size	~60,72kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 580~630 of Human TCF~4.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2