Rabbit polyclonal antibody to Fra~1 (D134)

The v~Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. Members of the c~Fos gene family, including c~Fos, Fos B, Fra~1 and Fra~2, encode nuclear phosphoproteins that are rapidly and transiently induced by a variety of agents and function as transcriptional regulators for several genes. In contrast to c~Jun proteins, which form homo~ and heterodimers that bind to specific DNA response elements, c~Fos proteins are only active as heterodimers with members of the Jun gene family. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP~1 and CRE sites.