Rabbit polyclonal antibody to HKR1 (W154)

Zinc~finger proteins contain DNA~binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc~finger proteins contain a Krueppel~type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HKR1, also known as Krueppel~related zinc finger protein 1 or zinc finger protein 875, is a 659 amino acid nuclear protein that is thought to play a role in transcriptional regulation. Existing as two alternatively spliced isoforms, HKR1 is a member of the Krueppel C2H2~type zinc~finger protein family and contains thirteen C2H2~type zinc fingers and one KRAB domain. The gene encoding HKR1 maps to human chromosome 19q13.12.