Rabbit polyclonal antibody to ALX3 (R203)

Aristaless~related genes are a group of paired~related homeobox genes which play a role in regulating vertebrate embryogenesis. The homeodomain transciption factor aristaless~like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, predominantly in neural crest~derived mesenchyme and in lateral plate mesoderm. Expression analysis of human and mouse tissue reveals predominant ALX3 expression in brain tissue. The Alx3 gene maps to chromosome 1p23~p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced~stage neuroblastoma and may repress ALX3 expression. Treatment with the methylation inhibitor 5~aza~2’~deoxycytidine restores ALX3 expression. Alx3 (~) mice lack a phenotype distinct from wild~type mice, however Alx3/Alx4 double mutants demonstrate severe craniofacial abnormalities not present in Alx4 single mutants. Specifically, Alx3/Alx4 double mutant newborn mice have cleft nasal regions in addition to malformation of other neural crest~derived skull structures.