Rabbit polyclonal antibody to Clock (E270)

Clock, a member of the basic~helix~loop~helix~PAS (bHLH~PAS) family of transcription factors, has also been identified as having circadian function. Mutations within the Clock gene have been shown to increase the length of the endogenous period and to cause a loss of rhythmicity of circadian oscillations. Clock contains a DNA~binding domain, a protein dimerization domain and a glutamine~rich C~terminal region, which indicates transactivation capabilities. It has been speculated that Clock may regulate circadian rhythmicity in combination with other proteins such as Per.