搜索

热搜关键词：
P16
IRAK4
GPC3
MMP9
IL28A
EPCAM
MK167
HAS2

请登录

提醒成功

QQ登录

微信登录

同意并阅读使用条款和隐私策略

账号密码登录

微信/QQ登录

没有账号？立即注册

搜索

抗体销售咨询健康评估咨询 mRNA-LNP咨询

0731-88388785

首页 > 产品中心 > 产品详情

Rabbit polyclonal antibody to NIPA (S350)

Western blot (WB) analysis of NIPA (S350) pAb at 1:500 dilution Lane1:PC3 whole cell lysate(20ug) Lane2:K562 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(10ug) Lane4:AML~12 whole cell lysate(40ug)

Rabbit polyclonal antibody to NIPA (S350)

货号：
53452
别名：
Nuclear~interacting partner of ALK; Nuclear~interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC~type protein 1; ZC3HC1; NIPA; HSPC216
产品上架时间：
2024-01-01
应用：
WB IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q86WB0
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

分享
咨询
收藏

加入购物车

立即购买

Rabbit polyclonal antibody to NIPA (S350)

Description
Entry into mitosis is essentially driven by cyclin B1 which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear Interaction Partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation.

Description

Entry into mitosis is essentially driven by cyclin B1 which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear Interaction Partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation.

Specification
Aliases	Nuclear~interacting partner of ALK; Nuclear~interacting partner of anaplastic lymphoma kinase; hNIPA; Zinc finger C3HC~type protein 1; ZC3HC1; NIPA; HSPC216
Swissprot	Q86WB0
clone	8G2F9
WB Predicted band size	~60~65kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Synthetic peptide, corresponding to amino acids 318~372 of Human NIPA.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2