Rabbit polyclonal antibody to p47~phox (P300)

The heredity disease chronic granulomatous disease (CGF) has been linked to mutations in p47~phox and p67~phox. The cytosolic proteins p47~phox and p67~phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, respectively, are required for activation of the superoxide~producing NADPH oxidase in neutrophils and other phagocytic cells. During activation of the NADPH oxidase, p47~phox and p67~phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex. Both p47~phox and p67~phox contain two Src homology 3 (SH3) domains. The C~terminal SH3 doamin of p67~phox has been shown to interact with the proline rich domain of p47~phox, suggesting that p47~phox may faciliate the transport of p67~phox to the membrane.