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Rabbit polyclonal antibody to IKKγ (H81)

Western blot (WB) analysis of IKBKG pAb at 1:500 dilution Lane1:MEF whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:H1792 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug) Lane5:Panc1 whole cell lysate (40ug)

Rabbit polyclonal antibody to IKKγ (H81)

货号：
53450
别名：
NF~kappa~B essential modulator; NEMO; FIP~3; IkB kinase~associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa~B kinase subunit gamma; I~kappa~B kinase subunit gamma; IKK~gamma; IKKG; IkB kinase subunit gamma; NF~kappa~B essential modifier; IKBKG; FIP3; NEMO; IKK~γ
产品上架时间：
2024-01-01
应用：
WB IHC IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q9Y6K9
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to IKKγ (H81)

Description
Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase α (IKKα), previously designated CHUK, interacts with IkB~α and specifically phosphorylates I˚Bα on Serine 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKα is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL~1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

Description

Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase α (IKKα), previously designated CHUK, interacts with IkB~α and specifically phosphorylates I˚Bα on Serine 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKα is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL~1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

Specification
Aliases	NF~kappa~B essential modulator; NEMO; FIP~3; IkB kinase~associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa~B kinase subunit gamma; I~kappa~B kinase subunit gamma; IKK~gamma; IKKG; IkB kinase subunit gamma; NF~kappa~B essential modifier; IKBKG; FIP3; NEMO; IKK~γ
Swissprot	Q9Y6K9
clone	10C10B10
WB Predicted band size	~42kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 50~100 of Human IKKγ.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2