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Western blot (WB) analysis of BID (I72) pAb at 1:1000 dilution Lane1:HCT116 whole cell lysate(40ug) Lane2:SK~OVCAR3 whole cell lysate(40ug) Lane3:Jurkat whole cell lysate(40ug)

Rabbit polyclonal antibody to BID (I72)

货号：
53442
别名：
BH3~interacting domain death agonist; p22 BID; BID; BH3~interacting domain death agonist p15; p15 BID; BH3~interacting domain death agonist p13; p13 BID;,BH3~interacting domain death agonist p11; p11 BID; BID
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P55957
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to BID (I72)

Description
BID, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

Description

BID, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas.

Specification
Aliases	BH3~interacting domain death agonist; p22 BID; BID; BH3~interacting domain death agonist p15; p15 BID; BH3~interacting domain death agonist p13; p13 BID;,BH3~interacting domain death agonist p11; p11 BID; BID
Swissprot	P55957
clone	8F6D8
WB Predicted band size	~22kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic peptide, corresponding to amino acids 50~100 of Human BID.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2