Rabbit polyclonal antibody to PDCD4 (K453)

The transformation suppressor gene Pdcd~4 (programmed cell death gene 4) inhibits the tumor~promoter mediated transformation of mouse keratinocytes and is a potential tumor suppressor gene in the development of human lung cancer. Biochemical analysis suggests that the Pdcd~4 protein is involved in protein translation as well as in nuclear events. Pdcd~4 directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap~dependent translation initiation complex. Pdcd~4 also suppresses the transactivation of AP~1 responsive promoters by c~Jun, suggesting that the transformation~suppressor activity of Pdcd~4 might be due, at least in part, to the inhibition of c~Jun activity. In addition to affecting c~Jun phosphorylation, Pdcd~4 blocks the recruitment of the co~activator p300 by c~Jun.