Rabbit polyclonal antibody to NFATc4 (N670)

NFATc4 (nuclear factor of activated T cells, cytoplasmic, calcineurin~dependent 4) is a member of the nuclear factors of activated T cells DNA~binding transcription complex that influences cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. This complex consists of at least two components: a cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate in the formation of this complex. NFATc4 plays a role in the inducible expression of cytokine genes in T cells, including the induction of IL~2 and IL~4. p38 MAP kinase phosphorylates multiple residues in the NFAT homology domain of NFATc4.