Rabbit polyclonal antibody to ERAB (E135)

β~Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer’s disease. β~Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of β~Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum~associated β~Amyloid~binding protein. ERAB is characterized as a NAD+~dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer’s disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to β~Amyloid~induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that β~Amyloid induced cell death is mediated by ERAB.