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Rabbit polyclonal antibody to PLC β3 (D1099)

Western blot (WB) analysis of PLC β3 (D1099) polyclonal antibody at 1:500 dilution Lane1:CT~26 whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:HEK293T whole cell lysate(40ug) Lane4:Hela whole cell lysate(40ug)

Rabbit polyclonal antibody to PLC β3 (D1099)

货号：
53415
别名：
1~phosphatidylinositol 4,5~bisphosphate phosphodiesterase β~3; Phosphoinositide phospholipase C~β~3; Phospholipase C~β~3; PLC~β3; 1~phosphatidylinositol 4,5~bisphosphate phosphodiesterase beta~3; Phosphoinositide phospholipase C~beta~3; Phospholipase C~beta~3; PLC~beta~3; PLCB3; PLCβ3
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q01970
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to PLC β3 (D1099)

Description
A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2) with molecular weights ranging from 85 to 150 kDa. The γ~type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ~type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the α subunits of the Gq class of heterotrimeric G proteins and by certain βγ G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are as yet not resolved.

Description

A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2) with molecular weights ranging from 85 to 150 kDa. The γ~type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ~type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the α subunits of the Gq class of heterotrimeric G proteins and by certain βγ G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are as yet not resolved.

Specification
Aliases	1~phosphatidylinositol 4,5~bisphosphate phosphodiesterase β~3; Phosphoinositide phospholipase C~β~3; Phospholipase C~β~3; PLC~β3; 1~phosphatidylinositol 4,5~bisphosphate phosphodiesterase beta~3; Phosphoinositide phospholipase C~beta~3; Phospholipase C~beta~3; PLC~beta~3; PLCB3; PLCβ3
Swissprot	Q01970
clone	4C9F2
WB Predicted band size	~150kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 1080~1130 of Human PLC β3.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2