Rabbit polyclonal antibody to CD31/PECAM~1 (T709)

CD31 (Platelet Endothelial Cell Adhesion Molecule~1: PECAM~1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells and endothelial cells, and modulates cell adhesion, endothelial cell migration and angiogenesis. CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy~terminal tail upon various stimuli (e.g. mechanical stress or oxidative stress), presumably by Src family members. The tyrosine phosphorylation mediates associations with a number of SH2 domain containing binding partners such as PI3~kinase, SHIP, PLCγ and SHP~2. Thus, CD31 serves as a scaffold for various signaling molecules.