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Rabbit polyclonal antibody to PDE4D (H47)

Western blot (WB) analysis of PDE4D (H47) polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:sp2/0 whole cell lysate Lane3:H9C2 whole cell lysate

Rabbit polyclonal antibody to PDE4D (H47)

货号：
53376
别名：
cAMP~specific 3',5'~cyclic phosphodiesterase 4D; DPDE3; PDE43; PDE4D; DPDE3
产品上架时间：
2024-01-01
应用：
WB IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q08499
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥2180

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Rabbit polyclonal antibody to PDE4D (H47)

Description
Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A~D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q12.

Description

Phosphodiesterases (PDE) hydrolyze cAMP to 5’AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A~D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q12.

Specification
Aliases	cAMP~specific 3',5'~cyclic phosphodiesterase 4D; DPDE3; PDE43; PDE4D; DPDE3
Swissprot	Q08499
clone	3H10C2
WB Predicted band size	~91kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 30~70 Human PDE4D.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2