Rabbit polyclonal antibody to IRAK1 (T381)

Three structurally related ligands for IL~1Rs have been described. These include two agonists, IL~1α and IL~1β, and a specific receptor antagonist, IL~1Rα. Two distinct receptors designated IL~1RI and IL~1RII have been identified, each of which belong to the Ig superfamily. The preponderance of evidence suggests IL~1RI to be the functional IL~1 receptor. Binding of IL~1 to its cognate receptor results in the activation of the NFκB signaling pathway. The IL~1~dependent kinase termed IRAK (for IL~1 receptor~associated kinase) co~immunoprecipitates with activated IL~1RI and has been implicated as an upstream mediator of NFκB activation. Additional support for this assertion comes from the fact that a related Drosophila protein, Pelle, is a known upstream activator of Dorsal, the Drosophila homolog of NFκB.