Rabbit polyclonal antibody to SENP1 (D2)

SUMO (small ubiquitin~related modifier), a member of the ubiquitin~like protein family, regulates diverse cellular functions of a variety of target proteins including transcription, DNA repair, nucleocytoplasmic trafficking and chromosome segregation. SUMO precursor proteins undergo cleavage of the residues after the “GG” region by SUMO~specific proteases in maturation. This cleavage of the precursor is a prerequisite for subsequent sumoylation. The sentrin~specific (or SUMO~specific) protease (SENP) proteins belong to the peptidase C48 family and include SENP1~3 and SENP5~8. SENP1, SENP2 and SENP3 degrade UBL1 and SMT3H2 conjugates and subsequently release the monomers from sumoylated substrates.