Rabbit polyclonal antibody to CD95 (L315)

Cytotoxic T lymphocyte (CTL)~mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno~ surveillance against virus~infected or transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin~based process. Independently, a FASbased mechanism involves the transducing molecule FAS (also designated APO~1) and its ligand (FAS~L). The human FAS protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, certain of which undergo apoptosis in response to treatment with antibody to FAS.