Rabbit polyclonal antibody to SGK1 (E416)

Serum~ and glucocorticoid~regulated kinase (SGK), also known as SGK1, is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1. SGK is a downstream target of PI 3~kinase~stimulated growth factor signaling, with 3~phosphoinositide~dependent protein kinase 1 (PDK1) capable of phosphorylating the activation~loop of SGK at Threonine~256.