Rabbit polyclonal antibody to Synuclein~pan (A19)

The synuclein family members, including α~synuclein (also designated NACP for non~β amyloid component) and β~synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α~synuclein is localized to neuronal cell bodies and synapses. α~synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α~synuclein was found to be up~regulated, while β~synuclein is down~regulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α~synuclein has been found in patients with early onset Parkinson’s disease.