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Rabbit polyclonal antibody to MCM2 / BM28 (A11)

Western blot (WB) analysis of BM28 / MCM2 (A11) pAb at 1:500 dilution Lane1:SK~OVCAR3 whole cell lysate(40ug) Lane2:HCT116 whole cell lysate(40ug) Lane3:CT26 whole cell lysate(40ug) Lane4:The Testis tissue lysate of Rat(40ug)

Rabbit polyclonal antibody to MCM2 / BM28 (A11)

货号：
53258
别名：
DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog Nuclear protein BM28; MCM2; BM28; CCNL1; CDCL1; KIAA0030
产品上架时间：
2024-01-01
应用：
WB IHC IF IP
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P49736
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to MCM2 / BM28 (A11)

Description
The mini~chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATPbinding motif, which is predicted to mediate ATP~dependent opening of doublestranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the ostreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro.

Description

The mini~chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATPbinding motif, which is predicted to mediate ATP~dependent opening of doublestranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the ostreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro.

Specification
Aliases	DNA replication licensing factor MCM2; Minichromosome maintenance protein 2 homolog Nuclear protein BM28; MCM2; BM28; CCNL1; CDCL1; KIAA0030
Swissprot	P49736
clone	7G6F5
WB Predicted band size	~125kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids N~terminus of Human MCM2.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2