Rabbit polyclonal antibody to COPS3 (M408)

The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF~type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF~complexes. It is also involved in the phosphorylation of p53, c~Jun, I˚Bα and IRF~8, as well as CSN~dependent phosphorylation of p53, and c~Jun protects and promotes degradation by the Ubl system.