Rabbit polyclonal antibody to ErbB2/HER2 (T1242)

The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB~2, HER2), ErbB~3 (HER3), and ErbB~4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero~dimerization with other EGF receptor family members. Neu heterodimerization with ErbB~3 recruits heregulin, which induces phosphoinositide (PI) 3~kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses.