Rabbit polyclonal antibody to G3BP~1 (D226)

G3BP is one of the DNA~unwinding enzymes which prefers partially unwound 3'~tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP~dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA~binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras~GTPase~activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full~length nature of some of these variants has not been determined.