Rabbit polyclonal antibody to FOSL2 (S301)

The v~Fos oncogene was initially identified as the transforming gene of two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c~Fos, encodes a nuclear phosphoprotein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c~Jun proteins, which form homo~ and heterodimers which bind to specific DNA TPA response elements (TREs), c~Fos proteins are only active as heterodimers with members of the Jun gene family. Murine Fos B encodes a nuclear protein of 338 amino acids which has 70% homology with c~Fos, exhibits similar kinetics of expression as c~Fos and forms heterodimers with both c~Jun and Jun B, which bind to TRE DNA response elements. Functional homologs of c~Fos and Fos B include Fra~1 and Fra~2 genes.