Rabbit polyclonal antibody to CUL1 (Y761)

CUL~1, which is the mammalian homolog of yeast Cdc53, is an integral component of the E3 ubiquitin ligase complex designated SCF. The SCF (Skp1/CUL~1/F~box protein complex) consists of Skp1 associating with both CUL~1 and an F~box protein, such as Skp2, which determines the substrate specificity of the complex. CUL~1~mediated ubiquitination results in the degradation of cell cycle proteins cyclin D, p21 and cyclin E. Another cullin, CUL~3, facilitates the degradation of cyclin E independent of SCF activity, while CUL~2 associates with the tumor suppressing protein VHL and elongin B to form VBC complexes, which structurally resemble the SCF ligase.