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Rabbit polyclonal antibody to Catenin~β (I35)

Western blot (WB) analysis of Catenin~β (I35) pAb at 1:500 dilution Lane1:Hela whole cell lysate(40ug) Lane2:The Uterus tissue lysate of Rat(40ug) Lane3:The Embryo tissue lysate of Mouse(40ug)

Rabbit polyclonal antibody to Catenin~β (I35)

货号：
53191
别名：
Catenin β; Cateninβ; Catenin beta~1; Beta~catenin; CTNNB1; CTNNB; ORF Names: OK/SW~cl.35; PRO2286
产品上架时间：
2024-01-01
应用：
WB IHC IP
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P35222
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to Catenin~β (I35)

Description
β~Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β~catenin at Ser45. This phosphorylation event primes β~catenin for subsequent phosphorylation by GSK~3β. GSK~3β destabilizes β~catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β~catenin protein levels and have been found in many tumor cell lines.

Description

β~Catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β~catenin at Ser45. This phosphorylation event primes β~catenin for subsequent phosphorylation by GSK~3β. GSK~3β destabilizes β~catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β~catenin protein levels and have been found in many tumor cell lines.

Specification
Aliases	Catenin β; Cateninβ; Catenin beta~1; Beta~catenin; CTNNB1; CTNNB; ORF Names: OK/SW~cl.35; PRO2286
Swissprot	P35222
clone	6H4A7
WB Predicted band size	~92kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids N~terminus of Human Catenin~β.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2