Rabbit polyclonal antibody to Bcr (D171)

The Bcr gene, mapping on chromosome 22, was initially identified on the basis of its fusion with the c~Abl proto~oncogene on chromosome 9 resulting in the generation of the Philadelphia chromosome in 90~95% of patients with chronic myelogenous leukemia (CML). The Bcr gene encodes for the Breakpoint cluster region protein (Bcr). A consequence of this translocation is the generation of a Bcr/c~Abl mRNA encoding an activated c~Abl protein kinase. The Bcr gene has been shown to encode a 160 kDa GTPase~activating protein (GAP) specific for the Ras~related GTP~binding protein, Rac 1 p21. While it has been speculated that the Bcr protein may also stimulate Rac 2 p21 GTPase activity, it has no effect on Ras p21 or Rho p21 GTPases.