Rabbit polyclonal antibody to ATF2 (G56)

The transcription factor ATF~2 (also called CRE~BP1) binds to both AP~1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF~2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF~2. Cellular stress activates ATF~2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF~2 at these sites in vitro and in cells transfected with ATF~2.