Rabbit polyclonal antibody to APOB

Post~transcriptional editing of apolipoprotein B (apoB) mRNA is regulated by APOBEC1 (also designated human (or rat) small intestinal apolipoprotein B mRNA editing protein, HEPR, or REPR) in hepatic cells to achieve a steady state proportion of edited and unedited RNA molecules. Two forms of apoB are known to circulate in the plasma of mammals. apoB~100 is a protein primarily synthesized in the liver as a structural component of very~low~density lipoprotein particles. A truncated form of apoB~100, apoB~48, is synthesized in the small intestine and contains the amino~terminal 2,152 amino acids of the larger protein. This organ~specific partitioning of apoB production is the result of RNA editing of a common apoB gene.