Rabbit polyclonal antibody to Substance P

Substance P (also designated NK~1) is an active peptide, known as a Tachykinin, that affects diverse functions, including blood pressure regulation, peristalsis of the gut, salivation and the modulation of cellular immunity. Frag~ments of Substance P have differential binding capacities for Substance P receptors and have varying biological activities. For example, two amino~ terminal fragments of Substance P are able to evoke an increase in GABA release. NK~1 receptor (NK~1R), also designated Substance P receptor, binds to Tachykinin peptides, including Substance P, Substance K and Neuromedin K. In response to Substance P binding, NK~1R signals IL~12 production.