Rabbit polyclonal antibody to VPS34 (phospho~Ser249)

ULK1 and ULK2 (for UNC~51~like kinase) encode similar amino~terminal serine/threonine kinase domains, a proline/serine~rich (PS) domain, and a species conserved carboxyl~terminal domain. Both share homology with the UNC~51 kinase from Caenorhabditis elegans and the APG1 kinase in yeast, which are involved in axonal extension and growth, and autophagy, respectively. ULK1 and ULK2 are thought to auto~phosphorylate the PS domain in vitro, and the significant homology among vertebrates suggest that ULK1 and ULK2 are involved in the regulation of fundamental biological processes.