Rabbit polyclonal antibody to PRGC1 (T56)

PPARγ coactivator~1α (PGC~1α) was originally identified as a transcriptional coactivator whose expression closely correlated with adaptive thermogenesis following exposure to cold temperatures. Named for its association with the nuclear receptor peroxisome~proliferator activated receptor (PPARγ), PGC~1α interacts with a diverse array of transcription factors to regulate numerous aspects of cell physiology. PGC~1α helps to regulate cell processes important in adaptive thermogenesis and energy metabolism, including the related functions of glucose uptake, gluconeogenesis, insulin secretion, and mitochondrial biogenesis. Long thought to be a potential therapeutic target for the treatment of type II diabetes, obesity, cardiomyopathy, or other metabolic disorders (reviewed in 4), a recent functional survey found no obvious differences in PPARγ activity associated with recognized PGC~1α variants.