Rabbit polyclonal antibody to ATG12 (A98)

Autophagy is a catabolic process for the autophagosomic~lysosomal degradation of bulk cytoplasmic contents. Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer. The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy~related (Atg) genes. Formation of the autophagosome involves a ubiquitin~like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. This conjugation reaction is mediated by the ubiquitin E1~like enzyme Atg7 and the E2~like enzyme Atg10.