Rabbit polyclonal antibody to Catenin~β (T41/S45)

β~catenin is a key downstream effector in the Wnt signaling pathway. It is implicated in two major biological processes in vertebrates: early embryonic development and tumorigenesis. CK1 phosphorylates β~catenin at Ser45. This phosphorylation event primes β~catenin for subsequent phosphorylation by GSK~3β. GSK~3β destabilizes β~catenin by phosphorylating it at Ser33, Ser37, and Thr41. Mutations at these sites result in the stabilization of β~catenin protein levels and have been found in many tumor cell lines.