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Rabbit polyclonal antibody to ERK1/2 (T202/Y204)

Western blot (WB) analysis of ERK1/2 pAb at 1:500 dilution Lane1:U~87MG whole cell lysate(40ug) Lane2:H9C2 whole cell lysate(40ug) Lane3:EC9706 whole cell lysate(40ug)

Rabbit polyclonal antibody to ERK1/2 (T202/Y204)

货号：
53083
别名：
Mitogen~activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal~regulated kinase 1; ERK~1; Insulin~stimulated MAP2 kinase; MAP kinase isoform p44; p44~MAPK; Microtubule~associated protein 2 kinase; p44~ERK1; MAPK3; ERK1; PRKM3; Mitogen~activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal~regulated kinase 2; ERK~2; MAP kinase isoform p42; p42~MAPK; Mitogen~activated protein kinase 2; MAP kinase 2; MAPK 2; MAPK1; ERK2; PRKM1; PRKM2
产品上架时间：
2024-01-01
应用：
WB IF
反应种属：
Human,Rat,Mouse
抗体类型：
Primary antibody
Swissprot：
P27361/P28482
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1180

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Rabbit polyclonal antibody to ERK1/2 (T202/Y204)

Description
The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular~signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr~ Glu~Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos~phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf~1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Description

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular~signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and Threonine sites mapping within a characteristic Thr~ Glu~Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phos~phorylate downstream components on Serine and Threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf~1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Specification
Aliases	Mitogen~activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal~regulated kinase 1; ERK~1; Insulin~stimulated MAP2 kinase; MAP kinase isoform p44; p44~MAPK; Microtubule~associated protein 2 kinase; p44~ERK1; MAPK3; ERK1; PRKM3; Mitogen~activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal~regulated kinase 2; ERK~2; MAP kinase isoform p42; p42~MAPK; Mitogen~activated protein kinase 2; MAP kinase 2; MAPK 2; MAPK1; ERK2; PRKM1; PRKM2
Swissprot	P27361/P28482
clone	5E8A10
WB Predicted band size	~45kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Rat,Mouse
Immunogen	Synthetic peptide, corresponding to amino acids 180~220 of Human ERK1.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2