Rabbit polyclonal antibody to Tak1 (phospho~T184)

Several serine/threonine protein kinases have been implicated as intermediates in signal transduction pathways. These include ERK/MAP kinases, ribosomal S6 kinase (Rsk) and Raf~1. Raf~1 is a protein with intrinsic kinase activity towards serine/threonine residues and that is widely expressed in many tissue types and cell lines. Raf~1 activation is dependent on the small molecular weight GTPase Ras, but the means by which this activation occurs is poorly understood. Two proteins putatively involved in this process are Ksr~1 and Tak1. Ksr~1 (kinase suppressor of Ras) is a novel Raf~related protein kinase whose function is required for Ras signal transduction. Whether Ksr~1 lies directly downstream of Ras or acts in a parallel pathway is not yet known. Tak1 (TGFß~activated kinase) has been shown to participate in the activation of the MAP kinase family in response to TGFß stimulation.