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Rabbit polyclonal antibody to PKC δ (phospho~T505)

Western blot (WB) analysis of PKC δ (phospho~T505) polyclonal antibody at 1:500 dilution Lane1:MCF~7 whole cell lysate Lane2:MCF~7 treated with LPS(100ng/ml) for 5 minutes whole cell lysate Lane3:MCF~7 treated with LPS(100ng/ml) for 30 minutes whole cell lysate Lane4:BV2 whole cell lysate(40ug) Lane5:PC12 whole cell lysate(40ug)

Immunoprecipitation of L02 cell lysate using PKC δ (phospho~T505) pAb (Sepharose Bead Conjugate) (lane 2 and lane 3) and Nonspecific IgG Control (Sepharose Bead Conjugate) (lane 4) .Lane 1 is 30% input. The western blot was probed using SHP~2 (E574) pAb .“↑”（supernatant）; “↓”（deposition）

Rabbit polyclonal antibody to PKC δ (phospho~T505)

货号：
53043
别名：
Protein kinase C delta type; Tyrosine~protein kinase PRKCD; nPKC~delta; Sphingosine~dependent protein kinase~1; SDK1; PRKCD; PKCδ
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q05655
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to PKC δ (phospho~T505)

Description
Protein Kinase C delta (PKC delta) is a 78 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC delta is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of multiple cellular processes including cell cycle progression and apoptosis. Autophosphorylation of serine 664 (serine 662 in mouse and rat) contributes to PKC delta activity. Serum dependent phosphorylation of serine 664 is mediated by mTOR pathway, is protected from dephosphorylation by phosphorylated threonine 505 in the activation loop, and is implicated in prolactin signaling.

Description

Protein Kinase C delta (PKC delta) is a 78 kDa member of the novel group (nPKCs: sensitive to diacylglycerol, phosphatidylserine, and phorbol esters) of the PKC family of serine/threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC delta is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of multiple cellular processes including cell cycle progression and apoptosis. Autophosphorylation of serine 664 (serine 662 in mouse and rat) contributes to PKC delta activity. Serum dependent phosphorylation of serine 664 is mediated by mTOR pathway, is protected from dephosphorylation by phosphorylated threonine 505 in the activation loop, and is implicated in prolactin signaling.

Specification
Aliases	Protein kinase C delta type; Tyrosine~protein kinase PRKCD; nPKC~delta; Sphingosine~dependent protein kinase~1; SDK1; PRKCD; PKCδ
Swissprot	Q05655
clone	5D6G10
WB Predicted band size	~80kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic phosphopeptide derived from human PKC δ around the phosphorylation site of Threonine 505.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2