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Rabbit polyclonal antibody to MSK1 (phospho~S360)

Western blot (WB) analysis of p~MSK1 (S360) polyclonal antibody at 1:500 dilution Lane1:MCF~7 whole cell lysate Lane2:MCF~7 treated with LPS(100ng/ml) for 5 minutes whole cell lysate Lane3:MCF~7 treated with LPS(100ng/ml) for 30 minutes whole cell lysate Lane4:AML~12 whole cell lysate(40ug) Lane5:H9C2 whole cell lysate(40ug)

Rabbit polyclonal antibody to MSK1 (phospho~S360)

货号：
53041
别名：
Ribosomal protein S6 kinase alpha~5; S6K~alpha~5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen~ and stress~activated protein kinase 1; RSK~like protein kinase; RSKL; RPS6KA5; MSK1
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
O75582
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to MSK1 (phospho~S360)

Description
MSK~1 is a mitogen and stress activated protein kinase~1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK~1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG~14 in response to mitogen and stress. Similar to RSK, MSK~1 contains two kinase domains (N~term and a C~term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK~1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C~terminal kinase domain of MSK~1 which is essential for the catalytic activity of the N~terminal kinase domain.

Description

MSK~1 is a mitogen and stress activated protein kinase~1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK~1can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG~14 in response to mitogen and stress. Similar to RSK, MSK~1 contains two kinase domains (N~term and a C~term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK~1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C~terminal kinase domain of MSK~1 which is essential for the catalytic activity of the N~terminal kinase domain.

Specification
Aliases	Ribosomal protein S6 kinase alpha~5; S6K~alpha~5; 90 kDa ribosomal protein S6 kinase 5; Nuclear mitogen~ and stress~activated protein kinase 1; RSK~like protein kinase; RSKL; RPS6KA5; MSK1
Swissprot	O75582
clone	6E7D6
WB Predicted band size	~90kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic phosphopeptide derived from human MSK1 around the phosphorylation site of Serine 360.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2