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Rabbit polyclonal antibody to IKKγ (Phospho~S31)

Western blot (WB) analysis of IKKγ (Phospho~S31) polyclonal antibody at 1:2000 dilution Lane1:HeLa whole cell lysate(40ug) Lane2:Hela treated with λ~phosphatase whole cell lysate(40ug)

Rabbit polyclonal antibody to IKKγ (Phospho~S31)

货号：
53039
别名：
NF~kappa~B essential modulator; NEMO; FIP~3; IkB kinase~associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa~B kinase subunit gamma; I~kappa~B kinase subunit gamma; IKK~gamma; IKKG; IkB kinase subunit gamma; NF~kappa~B essential modifier; IKBKG; FIP3, NEMO
产品上架时间：
2024-01-01
应用：
WB IF IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9Y6K9
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to IKKγ (Phospho~S31)

Description
Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase α (IKKα), previously designated CHUK, interacts with IkB~α and specifically phosphorylates I˚Bα on Serine 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKα is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL~1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

Description

Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in targeted degradation of IkB. IkB kinase α (IKKα), previously designated CHUK, interacts with IkB~α and specifically phosphorylates I˚Bα on Serine 32 and 36, the sites that trigger its degradation. IKKα appears to be critical for NFkB activation in response to proinflammatory cytokines. Phosphorylation of IkB by IKKα is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL~1. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IkB phosphorylation.

Specification
Aliases	NF~kappa~B essential modulator; NEMO; FIP~3; IkB kinase~associated protein 1; IKKAP1; Inhibitor of nuclear factor kappa~B kinase subunit gamma; I~kappa~B kinase subunit gamma; IKK~gamma; IKKG; IkB kinase subunit gamma; NF~kappa~B essential modifier; IKBKG; FIP3, NEMO
Swissprot	Q9Y6K9
clone	2C9B3
WB Predicted band size	~54kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic phosphopeptide derived from human IKKγ around the phosphorylation site of Serine 31.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.