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Rabbit polyclonal antibody to 4E~BP1 (Phospho~Thr70)

Western blot (WB) analysis of 4E~BP1(Phospho~Thr70) polyclonal antibody at 1:1000 dilution Lane1:HEK293T whole cell lysate(40ug) Lane2:HEK293T treated with 20% FBS for 30min whole cell lysate(40ug)

Rabbit polyclonal antibody to 4E~BP1 (Phospho~Thr70)

货号：
53019
别名：
Eukaryotic translation initiation factor 4E~binding protein 1; 4E~BP1; eIF4E~binding protein 1; Phosphorylated heat~ and acid~stable protein regulated by insulin 1; PHAS~I; EIF4EBP1
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q13541
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to 4E~BP1 (Phospho~Thr70)

Description
Translation repressor protein 4E~BP1 (also known as PHAS~1) inhibits cap~dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E~BP1 disrupts this interaction and results in activation of cap~dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E~BP1 activity. Multiple 4E~BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E~BP1 to eIF4E, it is thought to prime 4E~BP1 for subsequent phosphorylation at Ser65 and Thr70.

Description

Translation repressor protein 4E~BP1 (also known as PHAS~1) inhibits cap~dependent translation by binding to the translation initiation factor eIF4E. Hyperphosphorylation of 4E~BP1 disrupts this interaction and results in activation of cap~dependent translation. Both the PI3 kinase/Akt pathway and FRAP/mTOR kinase regulate 4E~BP1 activity. Multiple 4E~BP1 residues are phosphorylated in vivo. While phosphorylation by FRAP/mTOR at Thr37 and Thr46 does not prevent the binding of 4E~BP1 to eIF4E, it is thought to prime 4E~BP1 for subsequent phosphorylation at Ser65 and Thr70.

Specification
Aliases	Eukaryotic translation initiation factor 4E~binding protein 1; 4E~BP1; eIF4E~binding protein 1; Phosphorylated heat~ and acid~stable protein regulated by insulin 1; PHAS~I; EIF4EBP1
Swissprot	Q13541
clone	2F6G3
WB Predicted band size	~18kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human
Immunogen	Synthetic phosphopeptide derived from human 4E~BP1 around the phosphorylation site of Threonine 70.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.