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Rabbit polyclonal antibody to NPM (phospho~T199)

Western blot (WB) analysis of p~NPM (T199) pAb at 1:500 dilution Lane1:H1792 whole cell lysate(40ug) Lane2:A549 whole cell lysate(40ug) Lane3:SGC7901 whole cell lysate(40ug) Lane4:EC9706 whole cell lysate(40ug) Lane5:PC12 whole cell lysate(40ug) Lane6:CT26 whole cell lysate(40ug) Lane7:HEK293T whole cell lysate(40ug)

Rabbit polyclonal antibody to NPM (phospho~T199)

货号：
53015
别名：
Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; NPM1; NPM
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P06748
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to NPM (phospho~T199)

Description
Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

Description

Nucleophosmin (NPM; also known as B23, numatrin or NO38) is an abundant phosphoprotein primarily found in nucleoli. It has been implicated in several distinct cellular functions, including assembly and transport of ribosomes, cytoplasmic/nuclear trafficking, regulation of DNA polymerase α activity, centrosome duplication and molecular chaperoning activities. The NPM gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase. The NPM portion contributes to transformation by providing a dimerization domain, which results in activation of the fused kinase.

Specification
Aliases	Nucleophosmin; Nucleolar phosphoprotein B23; Nucleolar protein NO38; Numatrin; NPM1; NPM
Swissprot	P06748
clone	4C6H1
WB Predicted band size	~38kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic phosphopeptide derived from human NPM around the phosphorylation site of Threonine 199.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2