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Western blot (WB) analysis of SIRT2 pAb at 1:500 dilution Lane1:U~87MG whole cell lysate(40ug) Lane2:PC12 whole cell lysate(40ug) Lane3:AML~12 whole cell lysate(40ug) Lane4:HEK293T whole cell lysate(40ug)

Rabbit polyclonal antibody to SIRT2

货号：
53002
别名：
NAD~dependent protein deacetylase sirtuin~2; Regulatory protein SIR2 homolog 2; SIR2~like protein 2; SIRT2; SIR2L; SIR2L2
产品上架时间：
2024-01-01
应用：
WB
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q8IXJ6
规格：

50ul
100ul
数量：

-

+
说明书：

目录价¥1280

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Rabbit polyclonal antibody to SIRT2

Description
SIRT2 is a member of the sirtuin family of proteins. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono~ADP~ribosyltransferase activity. SIRT2 interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. SIRT2 is a NAD~dependent deacetylase, which deacetylates the 'Lys~40' of alpha~tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.

Description

SIRT2 is a member of the sirtuin family of proteins. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono~ADP~ribosyltransferase activity. SIRT2 interacts with HDAC6, suggesting that these proteins belong to a large complex that deacetylate the cytoskeleton. SIRT2 is a NAD~dependent deacetylase, which deacetylates the 'Lys~40' of alpha~tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Despite some ability to deacetylate histones in vitro, it is unlikely in vivo.

Specification
Aliases	NAD~dependent protein deacetylase sirtuin~2; Regulatory protein SIR2 homolog 2; SIR2~like protein 2; SIRT2; SIR2L; SIR2L2
Swissprot	Q8IXJ6
clone	8E1C9
WB Predicted band size	43kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at ~20°C long term. Avoid freeze~thaw cycles.
Species Reactivity	Human,Mouse,Rat
Immunogen	Synthetic peptide, corresponding to amino acids 330~380 of Human SIRT2.
Formulation	1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2