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Western blot analysis of extracts from 293 and Hela cells using HDAC4/HDAC5/HDAC9(Ab-246/259/220) Antibody P41548.

Immunofluorescence staining of methanol-fixed Hela cells using HDAC4/HDAC5/HDAC9(Ab-246/259/220) Antibody P41548.

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using HDAC4/HDAC5/HDAC9(Ab-246/259/220) Antibody P41548(left) or the same antibody preincubated with blocking peptide(right).

Rabbit Polyclonal Antibody to HDAC4/HDAC5/HDAC9(Ab-246/259/220)

货号：
P41548
别名：
HD4/HD5/HD9
产品上架时间：
2024-01-01
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P56524
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to HDAC4/HDAC5/HDAC9(Ab-246/259/220)

Description
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

Description

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.

References
Cress, W.D. and Seto, E. (2000) J Cell Physiol 184, 1-16. Vigushin, D.M. and Coombes, R.C. (2004) Curr. Cancer Drug Targets 4, 205-218. Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703. Thiagalingam, S. et al. (2003) Ann. N.Y. Acad. Sci. 983, 84-100.

Specification
Aliases	HD4/HD5/HD9
Entrez GeneID	9759;
Swissprot	P56524
WB Predicted band size	140 124 111 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Peptide sequence around aa.244~248/257~261/218~222 (T-A-S-E-P) derived from Human HDAC4/HDAC5/HDAC9.
Formulation	Purified antibody in PBS with 0.05% sodium azide.