Rabbit Monoclonal Antibody to AF10

Description
Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation (PubMed:26439302).

Specification
Aliases	MLLT10; AF10; Protein AF-10; ALL1-fused gene from chromosome 10 protein
Entrez GeneID	8028
Swissprot	P55197
WB Predicted band size	Calculated MW: 113 kDa; Observed MW: 140 kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human
Immunogen	Recombinant protein of human AF10
Formulation	Purified antibody in TBS with 0.05% sodium azide,0.05%BSA and 50% glycerol.

Application
WB	1/500-1/1000
IHC	1/50-1/100