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Gel: 12%SDS-PAGE Lysates (from left to right): Mouse brain tissue Amount of lysate: 40ug per lane Primary antibody: 1/1000 dilution Secondary antibody dilution: 1/8000 Exposure time: 2 minutes

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue using P42744 at dilution 1/50.

Rabbit Polyclonal Antibody to PCP4

货号：
P42744
别名：
PEP-19
产品上架时间：
2024-01-01
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P48539
规格：

100μl
50μl
数量：

-

+
说明书：

目录价¥1980

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Rabbit Polyclonal Antibody to PCP4

Description
PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer隆炉s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Description

PCP-4 (Purkinje cell protein 4), also known as PEP-19, is a calmodulin (CaM) regulatory protein that is highly expressed in neuronal cells. Through its IQ motif, PCP-4 mediates both the calcium-dependent binding properties of CaM and the rates of association and dissociation of calcium from the C-terminal domain of CaM. The IQ motif contains a serine residue which can be phosphorylated by all isoforms of protein kinase C (PKC). PCP-4 is implicated in uterine leiomyomas, as well as in neurodegenerative disorders such as Alzheimer隆炉s disease and Huntington's disease. Additionally, overexpression of PCP-4 is thought to play a role in cerebellar hypoplasia, a key feature of Down syndrome.

Specification
Aliases	PEP-19
Entrez GeneID	5121;
Swissprot	P48539
WB Predicted band size	7kDa
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human,Mouse
Immunogen	Fusion protein corresponding to a region derived from internal residues of human purkinje cell protein 4
Formulation	Purified antibody in PBS with 0.05% sodium azide.