Rabbit Polyclonal Antibody to MED27

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.Humphray S.J., Nature 429:369-374(2004).The MGC Project Team, Genome Res. 14:2121-2127(2004).Ryu S., Nature 397:446-450(1999).