Rabbit Polyclonal Antibody to SIX5

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter By similarity. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 By similarity.Boucher C.A., Hum. Mol. Genet. 4:1919-1925(1995).Grimwood J., Nature 428:529-535(2004).The MGC Project Team; Genome Res. 14:2121-2127(2004).