Rabbit Polyclonal Antibody to SLC27A5

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.Steinberg S.J., Mol. Genet. Metab. 68:32-42(1999).Steinberg S.J., J. Biol. Chem. 275:15605-15608(2000).Mihalik S.J., J. Biol. Chem. 277:24771-24779(2002).